Effect of Qijiaoshengbai Capsule combined with LEEP in the treatment of cervical precancerous lesions
芪胶生白胶囊合LEEP术治疗宫颈癌前病变的效果

摘要

目的 分析宫颈癌前病变者实施芪胶生白胶囊合LEEP术治疗的效果。方法 选择近3年（2018年12月-2021年12月）本院普查出的宫颈癌前病变者56例，年龄在40-50岁（平均45.32±2.48岁），未生育8例（39.29%）、已生育48例（60.71%），均在CINⅡ-Ⅲ级。所有病人均接受超高频电波刀（LEEP）手术治疗，其中27例在术后给予芪胶生白胶囊治疗，对他们临床治疗进行回顾性分析。其中实施LEEP手术+芪胶生白胶囊治疗的对象作为观察组，对临床治疗效果进行观察、分析。结果 56例患者均成功实施LEEP手术，病灶一次完全切除率达96.43%（54/56），其中2例（CINⅢ级）LEEP术后病检有微浸润，即性子宫全切术。所有患者平均手术时间3-12min（平均7.51±3.24min），术中平均出血量9-12ml（平均10.51±2.14ml）。有2例术中疼痛，3例术后下腹坠胀感，其他患者均无术后不适感，且均无复发病灶；对比所有患者实施手术治疗前后检查结果，其中术后，观察组病理级别下降率明显，治愈率较高，与对照组相比差异有统计学意义（P<0.05）；发放满意度调查表，两组患者满意度均在90%以上，且观察组满意度更高，与对照组相比差异有统计学意义（P<0.05）。结论 LEEP术治疗宫颈癌前病变有确切效果，可作为首选治疗手段。同时配合芪胶生白胶囊治疗，能进一步提高临床疗效，安全性高，临床应用价值显著。

Abstract

Objective To analyze the effect of Qijiaoshengbai capsule combined with LEEP in the treatment of cervical precancerous lesions.
Methods a total of 56 cases of precancerous cervical cancer diagnosed in our hospital in recent 3 years (December 2018 to December 2021) were selected, aged between 40 and 50 years old (average 45.32±2.48 years old), 8 cases (39.29%) had not given birth and 48 cases (60.71%) had given birth, all of which were CIN ⅱ-ⅲ. All patients received ULTRA-high frequency electric wave knife (LEEP) surgery, and 27 of them were treated with Qijiaoshengbai capsule after surgery. Their clinical treatment was retrospectively analyzed. LEEP operation and Qijiaoshengbai capsule were used as the observation group to observe and analyze the clinical treatment effect.
Results All 56 patients were successfully treated with LEEP, and the one-time complete resection rate of lesions was 96.43% (54/56). Among them, 2 cases (CIN ⅲ grade) showed microinfiltration after LEEP, namely total hysterectomy. The mean operation time of all patients was 3-12min (mean 7.51±3.24min), and the mean intraoperative blood loss was 9-12ml (mean 10.51±2.14ml). There were 2 cases of intraoperative pain, 3 cases of postoperative abdominal distension, and the other patients had no postoperative discomfort, and no recurrent lesions. The examination results of all patients before and after surgical treatment were compared. After surgery, the pathological grade decline rate was obvious in the observation group, and the cure rate was higher, and the difference was statistically significant compared with the control group (P<0.05). The satisfaction questionnaire showed that the satisfaction of patients in both groups was above 90%, and the observation group was more satisfied, with statistical significance compared with the control group (P<0.05).
Conclusion   LEEP is effective in the treatment of cervical precancerous lesions and can be used as the first choice of treatment. At the same time, the treatment with Qijiaoshengbai capsule can further improve the clinical efficacy, high safety and significant clinical application value.