Value of progesterone in the treatment of threatened abortion due to luteal insufficiency
黄体酮治疗黄体功能不全所致先兆流产的价值

摘要

目的 对黄体功能不全所致先兆流产患者使用黄体酮进行治疗的效果做出分析。方法 对2020年6月-2021年12月期间前来本院治疗的68例黄体功能不全所致先兆流产患者进行研究，根据随机抽样法把患者随机分成常规组（34例）和研究组（34例）。常规组患者使用常规对症治疗，研究组使用黄体酮进行治疗，观察患者治疗效果（治疗有效率、不良反应发生率、临床症状消失时间、血清孕酮水平、β-人绒毛膜促性腺激素水平）。结果 研究组治疗有效率为97.06%，高于常规组，组间差异明显（χ2=6.275，P=0.012），具有统计学意义。研究组不良反应发生率为5.88%，低于常规组，组间差异明显（χ2=5.314，P=0.021），具有统计学意义。研究组临床症状消失时间中，阴道流血消失时间、下腹疼痛消失时间分别为（8.02±1.02）d、（7.09±1.06）d，均短于常规组，组间差异明显（T=10.105，8.705，P<0.001），具有统计学意义。研究组β-人绒毛膜促性腺激素水平为（18996.61±415.42）mIU/mL，高于参照组，组间差异明显（T=70.700,P<0.001），具有统计学意义。结论 为黄体功能不全所致先兆流产患者使用黄体酮进行治疗，可以减少患者不良反应，缩短患者症状消失时间，且可以改善患者血清孕酮和β-人绒毛膜促性腺激素水平，治疗效果显著，临床应用价值较高。

Abstract

Objective To analyze the therapeutic effect of progesterone in patients with threatened abortion caused by luteal insufficiency.
Methods 68 patients with threatened abortion due to luteal insufficiency who came to our hospital for treatment from June 2020 to December 2021 were studied. According to random sampling method, the patients were randomly divided into conventional group (34 cases) and study group (34 cases). The patients in the conventional group were treated with conventional symptomatic treatment, while the study group was treated with progesterone. The therapeutic effects (effective rate, incidence of adverse reactions, time to disappearance of clinical symptoms, serum progesterone level and β-human chorionic gonadotropin level) were observed.
Results The effective rate of treatment in the study group was 97.06%, which was higher than that in the conventional group. The difference between groups was significant (χ2=6.275, P=0.012). The incidence of adverse reactions in the study group was 5.88%, lower than that in the conventional group, with significant difference between groups (χ2=5.314, P=0.021). The disappearance time of vaginal bleeding and lower abdominal pain in the study group were (8.02 ± 1.02) days and (7.09 ± 1.06) days, respectively, shorter than those in the conventional group, with significant differences between groups (T=10.105,8.705, P<0.001). Research Group β- The level of human chorionic gonadotropin was (18996.61 ± 415.42) mIU/mL, which was higher than that of the reference group. The difference between groups was significant (T=70.700, P<0.001), with statistical significance.
Conclusion   Progesterone therapy for threatened abortion patients caused by luteal insufficiency can reduce adverse reactions, shorten the time of symptom disappearance, and improve the serum levels of progesterone and β-human chorionic gonadotropin in patients. The therapeutic effect is significant, and the clinical application value is high.