期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据:

Open Access Article

International Journal of Obstetrics and Gynecology. 2022; 2: (4) ; 10-13 ; DOI: 10.12208/j.ijog.20220072.

Research progress of bacterial vaginosis in the pathogenesis of cervical cancer
细菌性阴道病在宫颈癌发病机制中的研究进展

作者: 武艳芳, 索静 *

内蒙古医科大学附属医院妇产科 内蒙古呼和浩特

*通讯作者: 索静,单位:内蒙古医科大学附属医院妇产科 内蒙古呼和浩特;

发布时间: 2022-12-28 总浏览量: 607

摘要

分析细菌性阴道病在宫颈癌变中可能的发病机制。女性生殖道感染是宫颈癌发病的重要原因之一,其中细菌性阴道病在宫颈癌致病中尤其重要。细菌性阴道病以乳酸杆菌减少,而其他病原菌如加德纳菌、各种厌氧菌等的大量繁殖为特征。细菌性阴道病与女性性传播疾病、生殖系统炎性疾病、不孕症和不良妊娠结局等多种疾病相关,已经严重影响我国女性的健康。阐明细菌性阴道病在宫颈癌致病机制中的作用,将有利于临床宫颈癌的防治,降低宫颈癌的发病率。

关键词: 细菌性阴道病;宫颈癌;致病机制

Abstract

To analyze the possible pathogenesis of bacterial vaginosis in cervical carcinogenesis.Female genital tract infection is one of the important causes of cervical cancer, and bacterial vaginosis is particularly important in the pathogenesis of cervical cancer. Bacterial vaginosis is characterized by the reduction of lactobacillus and the proliferation of other pathogenic bacteria such as Gardnerella and various anaerobic bacteria. Bacterial vaginosis is related to many diseases such as female sexually transmitted diseases, reproductive system inflammatory diseases, infertility and adverse pregnancy outcomes, which has seriously affected the health of women in China.To clarify the role of bacterial vaginosis in the pathogenesis of cervical cancer will be conducive to the prevention and treatment of clinical cervical cancer and reduce the incidence rate of cervical cancer.

Key words: Bacterial vaginosis; Cervical cancer; Pathogenic mechanism

参考文献 References

[1] 张军.宫颈癌治疗的现状及问题:从临床指南到真实世界研究[J]. 中国全科医学,2022,25(3):259-263.

[2] Hull R, Mbele M, Makhafola T, Hicks C, Wang SM, Reis RM, Mehrotra R, Mkhize-Kwitshana Z, Kibiki G, Bates DO, Dlamini Z. Cervical cancer in low and middle-income countries. Oncol Lett. 2020 Sep;20(3):2058-2074.

[3] Platz-Christensen J J,Larsson P G,Sundström E,Bondeson L. Detection of bacterial vaginosis in Papanicolaou smears.[J]. American journal of obstetrics and gynecology,1989,160(1).

[4] Łaniewski P, Herbst-Kralovetz MM. Bacterial vaginosis and health-associated bacteria modulate the immunometabolic landscape in 3D model of human cervix. NPJ Biofilms Microbiomes. 2021 Dec 13;7(1):88. 

[5] 李健芳,冯勤梅,孙晋瑞,王亚荣,袁卫艳,郭路路,刘萍.阴道微生态与免疫微环境的变化对宫颈癌的影响[J].中国微生态学杂志,2022,34(04):493-497.

[6] Maarsingh JD, Łaniewski P, Herbst-Kralovetz MM. Immunometabolic and potential tumor-promoting changes in 3D cervical cell models infected with bacterial vaginosis-associated bacteria. Commun Biol. 2022 Jul 22;5(1):725.

[7] 杨彩虹,孟焕然.宫颈癌患者阴道微生态变化及其与细胞免疫的相关性探讨[J].中国微生态学杂志,2022,34(02):210-215.

[8] 伍凤莉,周丹,吕秋波,魏风华.宫颈癌前病变及宫颈癌患者阴道微生态评价[J].中国临床医生杂志,2018,46(11):1344-1346.

[9] 凌若兰,祝秀芝,宁玉梅.阴道加德纳菌的致病机制及其导致的生殖道感染问题的相关研究进展[J].中国妇幼保健,2022,37(09):1741-1744.

[10] Reiter Suzanne and Kellogg Spadt Susan. Bacterial vaginosis: a primer for clinicians.[J]. Postgraduate medicine, 2019, 131(1) : 8-18.

[11] Teng P, Hao M. A population-based study of age-related associations between vaginal pH and the development of cervical intraepithelial neoplasia. Cancer Med. 2020 Mar;9(5):1890-1902.

[12] 陆乐,曹维维,丁亚沙,厉叶青,王静静.阴道微生态及酶改变与高危型人乳头瘤病毒感染及宫颈上皮内瘤变发生风险的相关性研究[J].中国性科学,2022,31(08):94-98.

[13] 徐秀颖,王英红.阴道微生态与高危型人乳头瘤病毒感染及宫颈病变的相关性[J].中国微生态学杂志,2021,33(05):586-590.

[14] 朱若熙,郝敏,赵卫红,王伟,王志莲,王金桃,冯波,杨婧,王哲,牛晓芬.阴道微生物代谢产物及酶改变与高危型人乳头瘤病毒感染和宫颈上皮内瘤变发生风险的关系[J].中国实用妇科与产科杂志,2019,35(07):797-802.

[15] Belleti R, Marcolino LD, Novak J, Ferreira CST, do Nascimento Bolpetti A, da Silva Pinto GV, de Oliveira AP, da Silva MG, Marconi C. Cervicovaginal loads of Gardnerella spp. are increased in immunocompetent women with persistent high-risk human papillomavirus infection. J Med Microbiol. 2022 May;71(5).

[16] 王景妹,韩凤贤,徐世亮,柯艺文.宫颈病变患者阴道微生态及高危型人乳头瘤病毒感染分析[J].中华医院感染学杂志,2021,31(07):1061-1066.

[17] 陈婉珍,吴林玲,闫颖.人乳头瘤病毒(HPV)感染与阴道微生态的相关性研究[J].中国微生态学杂志,2017,29(07):832-834.

[18] 凌若兰,祝秀芝,宁玉梅.阴道加德纳菌的致病机制及其导致的生殖道感染问题的相关研究进展[J].中国妇幼保健,2022,37(09):1741-1744.

[19] Yang X, Da M, Zhang W, Qi Q, Zhang C, Han S. Role of Lactobacillus in cervical cancer. Cancer Manag Res. 2018 May 16;10:1219-1229. 

[20] 中华医学会妇产科学分会感染性疾病协作组.细菌性阴道病诊治指南(2021修订版)[J].中华妇产科杂志,2021,56(01):3-6.

[21] 高月倩,白君宜,王辰,李会阳,董梦婷,高超,范爱萍,薛凤霞.2021年美国疾病控制和预防中心《性传播感染治疗指南》关于阴道炎症的诊治规范解读[J].中国实用妇科与产科杂志,2021,37(11):1141-1146.

引用本文

武艳芳, 索静, 细菌性阴道病在宫颈癌发病机制中的研究进展[J]. 国际妇产科研究, 2022; 2: (4) : 10-13.