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Open Access Article

International Journal of Obstetrics and Gynecology. 2022; 2: (4) ; 1-6 ; DOI: 10.12208/j.ijog.20220070.

Kiss1 and Polycystic Ovary Syndrome
Kiss1和多囊卵巢综合征

作者: 王召军, 司马健 *

中国药科大学 江苏南京

*通讯作者: 司马健,单位:中国药科大学 江苏南京;

发布时间: 2022-12-28 总浏览量: 391

摘要

Kiss1基因对于人类以及哺乳动物青春期的发育极为重要。Kiss1基因编码的下丘脑肽Kisspeptin是调节促性腺激素释放激素分泌的复杂兴奋网络的重要组成部分。完整的Kisspeptin-GnRH信号系统对于哺乳动物的正常生殖成熟和生育能力是必不可少的。多囊卵巢综合征是育龄妇女最常见的疾病之一,在全球范围内影响高达15%。多囊卵巢综合征的发病机制尚不清楚,因此临床上尚无可以治愈的药物,但Kisspeptin-GnRH信号系统与多囊卵巢综合征密切相关。本综述主要介绍了Kiss1基因及其信号系统和多囊卵巢综合征的病理特征及治疗方式的相关研究进展。

关键词: Kiss1;Kisspeptin;GPR54;PCOS

Abstract

Kiss1 gene is very important for human and mammalian puberty development. The hypothalamic peptide kisspeptin encoded by kiss1 gene is an important part of the complex excitatory network that regulates the secretion of gonadotropin releasing hormone. A complete Kisspeptin GnRH signal system is essential for the normal reproductive maturity and fertility of mammals. Polycystic ovary syndrome (PCOS) is one of the most common diseases in women of childbearing age, affecting up to 15% of the world. The pathogenesis of polycystic ovary syndrome (PCOS) is still unclear, so there is no clinically curable drug, but Kisspeptin GnRH signal system is closely related to PCOS. This review mainly introduced the research progress of Kiss1 gene and its signal system, pathological characteristics and treatment of polycystic ovary syndrome.

Key words: Kiss1; Kisspeptin; GPR54; PCOS

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引用本文

王召军, 司马健, Kiss1和多囊卵巢综合征[J]. 国际妇产科研究, 2022; 2: (4) : 1-6.