Effect analysis of progesterone combined with low molecular weight heparin sodium in the treatment of recurrent abortion
黄体酮联合低分子肝素钠治疗复发性流产的效果分析

摘要

目的 分析在对复发性流产患者进行治疗的过程中按照黄体酮、低分子肝素钠进行治疗的效果。方法 按照对比治疗观察的方式展开探究，共计纳入患者80例，属于本院在2019年3月至2022年3月所收治患者，遵照双盲法分组的方式划分为2组，即对照组（40例，进行常规治疗）和观察组（40例，按照黄体酮、低分子肝素钠共同治疗）。对比患者的恢复情况。结果 结合对两组患者在治疗期间D二聚体水平、纤维蛋白原水平以及纤维蛋白降解产物水平检测，在治疗前两组无明显差异，P>0.05，在治疗后观察组明显优于对照组，P<0.05。统计两组绒毛膜促性腺激素水平、孕酮水平以及雌二醇水平，在治疗前两组无差异，P>0.05，在治疗后，观察组各激素水平均优于对照组，P<0.05。统计患者在治疗期间出血症状、腹部疼痛症状、腰酸坠胀症状改善时间，观察组用时均短于对照组，P<0.05。对比患者在治疗期间的不良反应情况，观察组不良反应发生率低于对照组，P<0.05。结论 在对复发性流产患者进行保胎治疗的过程中按照黄体酮、低分子肝素钠进行治疗能够迅速缓解患者对应症状，并改善患者的激素水平以及凝血功能，有助于改善妊娠结局。

Abstract

Objective: To analyze the effect of progesterone and low molecular weight heparin sodium in the treatment of patients with recurrent abortion.
Methods: Inquiry according to the comparative observation of the treatment, 80 patients with total into, belong to our hospital from March 2019 to March 2022 treated patients, according to the grouping double-blind way is divided into two groups, namely the control group (40 cases, carries on the routine therapy) and observation group (40 cases, according to the progesterone, low molecular heparin therapy) together. Compare the patient's recovery.
Results: The levels of D-dimer, fibrinogen and fibrin degradation products of the two groups during the treatment showed no significant difference between the two groups before treatment (P>0.05). After treatment, the observation group was significantly better than the control group (P<0.05). The levels of chorionic gonadotropin, progesterone and estradiol in the two groups were statistically analyzed, and there was no difference between the two groups before treatment (P>0.05). After treatment, the levels of each hormone in the observation group were better than those in the control group (P<0.05). The improvement time of bleeding symptoms, abdominal pain symptoms and lumbar acid swelling symptoms during treatment was statistically analyzed, and the time of observation group was shorter than that of control group (P<0.05). Compared with the adverse reactions during treatment, the incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05).
Conclusion  : The treatment of progesterone and low molecular weight heparin sodium in the process of fetal preservation therapy for patients with recurrent abortion can quickly relieve the corresponding symptoms, improve the hormone level and coagulation function of patients, and help to improve the pregnancy outcome.